Design, synthesis and antiproliferative activity of two new heteroannelated (-)-muricatacin mimics |
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| Authors: | Popsavin Velimir Srećo Bojana Benedeković Goran Popsavin Mirjana Francuz Jovana Kojić Vesna Bogdanović Gordana |
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| Institution: | 1. Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia;2. Institute of Oncology Sremska Kamenica, Institutski put 4, 21204 Sremska Kamenica, Serbia |
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| Abstract: | Two new (-)-muricatacin mimics bearing a furano-furanone ring and an oxygen isostere in the side chain have been designed and synthesized and their in vitro antiproliferative activity was evaluated against several human tumour cell lines. Both analogues showed an increased activity against HL-60 cells with 17- and 185-fold higher potency than (-)-muricatacin. A straightforward synthesis of (-)-muricatacin is also disclosed. |
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