Manganese pre-treatment attenuates cadmium induced hepatotoxicity in Swiss albino mice |
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| Affiliation: | 1. Baotou Medical College, No. 31 Construction Road, Baotou, Inner Mongolia 014060, China;2. Inner Mongolia Institute of Traditional Chinese Medicine, Hohhot, Inner Mongolia 010020, China;1. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India;2. School of Pharmacy, Graphic Era Hill University Dehradun, Uttarakhand, India;3. Drug Design and Discovery Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture Technology and Sciences, Allahabad, India;4. Regional Medical Research Centre, ICMR, Dibrugarh, Assam, India;1. Departamento de Química Analítica, Facultad de Químicas, Complutense University of Madrid, Avenida Complutense s/n, 28040 Madrid, Spain;2. Laboratoire de Chimie Analytique Bio-Inorganique et Environnement, UMR 5254 CNRS - Université de Pau et des Pays de l''Adour, Pau, France;1. College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, PR China;2. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, PR China;3. Bijie Pilot Area Research Institute, Bijie University, Bijie 551700, PR China;1. Department of Automotive Engineering, School of Transportation Science and Engineering, Beihang University, Beijing, 100191, China;2. Advanced Vehicle Research Center (AVRC), Beihang University, Beijing, 100191, China;1. Univ. Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, UMR 8181 - UCCS - Unité de Catalyse et Chimie du Solide, F-59000 Lille, France;2. CRISMAT, CNRS, UMR 6508, ENSICAEN, Caen, France |
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| Abstract: | Cadmium (Cd) is a soft, malleable bluish-white metal with low melting point, a ubiquitous heavy metal and an environmental pollutant, found in soil, water and air. The presence of Cd in the components of the environment such as air, soil and groundwater is to a large part due to human activity, and the general population is exposed mainly by contaminated drinking water or food. Manganese (Mn) is a component in many enzymes, which play an important role in counteracting oxidative stress. In vitro experiments have revealed the ability of Mn to scavenge oxygen free radicals generated in differently mediated lipid peroxidation (LPO) conditions. The aim of the present study was to investigate the in vivo preventive effect of Mn2+ pre-treatment on acute Cd-intoxication with regard to oxidative stress biomarker and antioxidant defense system in liver of Swiss albino mice. On exposure to Cd a significant increase in LPO levels, decrease in thiol content and induction in glutathione metabolizing enzyme were observed. Mn pre-treatment attenuated the modulation caused in the above-mentioned parameters due to acute Cd exposure in mice. In conclusion, the results from this study demonstrate that the protective effect of Mn in Cd-induced systemic toxicity in mice. Further investigations are required on the relation between Mn accumulation and resistance to oxidative stress and on the factors influencing Mn/Cd transport in rodents are needed to elucidate the molecular basis of this protective effect. |
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| Keywords: | Cadmium Manganese Liver Oxidative stress Biomarker |
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