Serum and urinary selenium levels in obese children: A cross-sectional study |
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| Institution: | 1. Department of Analytical Chemistry, Medical University of Lublin, Poland;2. Department of Pediatric Endocrinology and Diabetology, Medical University of Lublin, Poland;3. Pomeranian University, Biology and Environmental Protection Institute, Environmental Chemistry Research Unit, S?upsk, Poland;4. Department of Pharmaceutical Microbiology, Medical University of Lublin, Poland;1. Discipline of Nutrition and Metabolism, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil;2. Pediatric Nephrology Section, Federal University of São Paulo, São Paulo, Brazil;3. Pediatric Intensive Care Unit, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil;4. Discipline of Allergy and Immunology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil;1. Department of Environmental and Occupational Health Sciences, University of Washington, 1959 Pacific St., Seattle, WA 98195, USA;2. Department of Biostatistics, University of Washington, 1705 NE Pacific St., Seattle, WA 98195, USA;3. Department of Health Services, University of Washington, 1959 Pacific St., Seattle, WA 98195, USA;4. Health and Safety Laboratory, Harpur Hill, Buxton, Derbyshire SK17 9JN, UK;1. Department of Physiology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia;2. Tissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia;3. KPJ Seremban Specialist Hospital, Negeri Sembilan, Malaysia;1. Department of Dermatology, Hospital Universitario de la Princesa, Madrid, Spain;2. Department of Rheumatology, Hospital Universitario de la Princesa, Madrid, Spain;3. Department of Pathology, Hospital Universitario de la Princesa, Madrid, Spain |
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| Abstract: | ObjectiveTo determine serum and urinary selenium (Se) levels in children with and without obesity, and to assess if Se influences the risk of obesity.Subjects and methodsHigh-resolution-continuum source-atomic absorption spectrometry (HR-CS-AAS) was used to determine the content of Se in 80 children (age 6–17; 40 boys, 40 girls). Correlations between variables were tested with the use of Spearman's correlation coefficient. U Mann–Whitney test was applied to assess the difference of Se contents in samples. Measured metabolic risk factors (blood pressure, glucose level, triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol), age, gender, and BMI were correlated. Logistic regression models were fitted to identify predictors of obesity interacting with selenium content in serum and urine, separately.ResultsObese children, regardless of gender, had lower Se content. Se level in serum (p = 0.001, OR 0.74, 95%CI 0.62–0.88) and total cholesterol (p = 0.001, OR 1.19, 95%CI 1.08–1.31) were the independent factors significantly influencing the risk of obesity in children. Two separate models were observed for Se in urine: (i) Se level (p < 0. 0001, OR 0.70, 95%CI 0.58–0.84) and glucose level (p < 0.0001, OR 1.22, 95%CI 1.10–1.35), and (ii) Se level (p = 0.002, OR 0.60 95%CI 0.43–0.83) and total cholesterol level (p = 0.003, OR 1.16, 95%CI 1.05–1.28).ConclusionThe current study suggests a possible role of Se in obesity. Further research needs to be performed to check if obese children are an at-risk group for Se deficiency. |
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| Keywords: | Selenium Childhood obesity Body fluids HR-CS-AAS |
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