Large naturally-produced electric currents and voltage traverse damaged mammalian spinal cord |
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| Authors: | Mahvash Zuberi Peishan Liu-Snyder Aeraj ul Haque David M Porterfield Richard B Borgens |
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| Affiliation: | (1) Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA;(2) Department of Biomedical Engineering, Brown University, Providence, RI, USA;(3) Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA;(4) Department of Agricultural and Biological Engineering, Department Horticulture and Landscape Architecture, Weldon School of Biomedical Engineering, Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA;(5) Center for Paralysis Research, School of Veterinary Medicine; Weldon School of Biomedical Engineering, College of Engineering, 408 S. University St., Purdue University, West Lafayette, IN, USA |
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| Abstract: | Background Immediately after damage to the nervous system, a cascade of physical, physiological, and anatomical events lead to the collapse of neuronal function and often death. This progression of injury processes is called "secondary injury." In the spinal cord and brain, this loss in function and anatomy is largely irreversible, except at the earliest stages. We investigated the most ignored and earliest component of secondary injury. Large bioelectric currents immediately enter damaged cells and tissues of guinea pig spinal cords. The driving force behind these currents is the potential difference of adjacent intact cell membranes. For perhaps days, it is the biophysical events caused by trauma that predominate in the early biology of neurotrauma. |
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