The brown adipocyte differentiation pathway in birds: An evolutionary road not taken |
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| Authors: | Nadejda V Mezentseva Jaliya S Kumaratilake Stuart A Newman |
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| Institution: | (1) Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA;(2) Discipline of Anatomical Sciences, University of Adelaide, Adelaide, SA, 5005, Australia |
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| Abstract: | Background Thermogenic brown adipose tissue has never been described in birds or other non-mammalian vertebrates. Brown adipocytes in
mammals are distinguished from the more common white fat adipocytes by having numerous small lipid droplets rather than a
single large one, elevated numbers of mitochondria, and mitochondrial expression of the nuclear gene UCP1, the uncoupler of
oxidative phosphorylation responsible for non-shivering thermogenesis. |
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