MPDA: Microarray pooled DNA analyzer |
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| Authors: | Hsin-Chou Yang Mei-Chu Huang Ling-Hui Li Chien-Hsing Lin Alice LT Yu Mitchell B Diccianni Jer-Yuarn Wu Yuan-Tsong Chen Cathy SJ Fann |
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| Affiliation: | (1) Institute of Statistical Science, Academia Sinica, Taipei, Taiwan;(2) Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan;(3) Department of Life Sciences and Institute of Genome Sciences, Yang-Ming University, Taipei, Taiwan;(4) Genomics Research Center, Academia Sinica, Taipei, Taiwan;(5) Department of Pediatrics/Hematology Oncology, University of California, San Diego, USA |
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| Abstract: | Background Microarray-based pooled DNA experiments that combine the merits of DNA pooling and gene chip technology constitute a pivotal advance in biotechnology. This new technique uses pooled DNA, thereby reducing costs associated with the typing of DNA from numerous individuals. Moreover, use of an oligonucleotide gene chip reduces costs related to processing various DNA segments (e.g., primers, reagents). Thus, the technique provides an overall cost-effective solution for large-scale genomic/genetic research. However, few publicly shared tools are available to systematically analyze the rapidly accumulating volume of whole-genome pooled DNA data. |
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