Additional signals from VPAC/PAC family receptors |
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| Authors: | McCulloch D A MacKenzie C J Johnson M S Robertson D N Holland P J Ronaldson E Lutz E M Mitchell R |
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| Affiliation: | MRC Membrane and Adapter Proteins Co-operative Group, Membrane Biology Group, Division of Biomedical and Clinical Laboratory Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK. |
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| Abstract: | The receptors for the neuropeptides vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide are strong activators of adenylate cyclase, but recent evidence suggests that they can elicit a number of additional intracellular signals. Some of these are likely to be downstream of the conventional adenylate cyclase pathway, but it is now clear that others reflect novel primary coupling events of the receptors. |
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