Toxicity assessment of the puffer fish Lagocephalus lagocephalus from the Tunisian coast |
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Authors: | Saoudi Mongi Abdelmouleh Abdelwaheb Kammoun Wassim Ellouze Feriel Jamoussi Kamel El Feki Abdelfattah |
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Affiliation: | Animal Ecophysiology Laboratory, Sciences Faculty of Sfax, Department of Life Sciences, Sfax, Tunisia. |
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Abstract: | This study was undertaken to assess the risk of poisoning due to consumption of the puffer fish Lagocephalus lagocephalus collected along the Tunisian coast. Wistar rats were daily intraperitoneally injected, for 10 days, with acidic extracts of liver or flesh (muscles + skin) of L. lagocephalus. Control rats received injections of NaCl (0.9%). No mortality and no evident signs of neurotoxicity were recorded in treated rats. Conversely, treatment led to: (1) diarrhoea and body and organ (liver, kidney) weights loss; (2) oxidative stress evidenced by an increase in lipid peroxidation (TBARS) and conversely a decrease in antioxidant enzyme activities (SOD, catalase, GSH-Px) in tissues (blood cells, liver, kidneys); (3) a decrease in alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in blood plasma. |
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Keywords: | Hepatotoxicity Lagocephalus lagocephalus Nephrotoxicity Antioxidant statusMots-clé s: Hé patotoxicité Lagocephalus lagocephalus Né phrotoxicité Statut antioxydant |
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