Epicatechin Inhibits Human Plasma Lipid Peroxidation Caused by Haloperidol In Vitro |
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Authors: | Anna Dietrich-Muszalska Bogdan Kontek Beata Olas Jolanta Rabe-Jabłońska |
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Institution: | (1) Department of Affective and Psychotic Disorders, Medical University of Lodz, Czechoslowacka 8/10, 92-216 Lodz, Poland;(2) Department of General Biochemistry, University of Lodz, Pomorska 141/3, 90-236 Lodz, Poland |
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Abstract: | Epicatechin belongs to flavonoids protecting cells against oxidative/nitrative stress. Oxidative/nitrative stress observed
in schizophrenia may be caused partially by the treatment of patients with various antipsychotics. The aim of our study was
to establish the effects of epicatechin and antipsychotics action (the first generation antipsychotic (FGA)—haloperidol and
the second generation antipsychotic (SGA)—amisulpride) on peroxidation of plasma lipids in vitro. Lipid peroxidation in human
plasma was measured by the level of thiobarbituric acid reactive species (TBARS). The properties of epicatechin were also
compared with the action of a well characterized antioxidative commercial polyphenol—resveratrol (3,4′,5-trihydroxystilbene)
and quercetin (3,5,7,3′,4′-pentahydroxyflavone). Amisulpride, contrary to haloperidol (after 1 and 24 h) does not significantly
influence the increase of plasma TBARS level in comparison with control samples (P > 0.05). After incubation (1 and 24 h) of plasma with haloperidol in the presence of epicatechin we observed a significantly
decreases the level of TBARS (P < 0.001, P < 0.001, respectively). In our other experiments, we found that epicatechin also decreased the amount of TBARS in human plasma
treated with amisulpride. In conclusion, the presented results indicate that epicatechin—the major polyphenolic component
of green tea reduced significantly human plasma lipid peroxidation caused by haloperidol. Moreover, epicatechin was found
to be a more effective antioxidant, than the solution of pure resveratrol or quercetin. |
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