Impact of Potential Blockers on Ru(III) Complex
Binding to Human Serum Albumin |
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Authors: | Lilianna Trynda-Lemiesz Marek ?uczkowski |
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Institution: | . Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, Wroclaw, 50-383, Poland, |
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Abstract: | The effects of aspirin, vitamin B2 and warfarin as potential blockers of the ruthenium binding sites in
HSA were investigated through UV/visible, circular dichroism (CD), fluorescence spectroscopy and the
inductively coupled plasma-atomic emission spectroscopy ICP(AES). The studies on the interactions of
several biologically relevant molecules with HSA have shown that drugs like aspirin or warfarin may
strongly influence the interaction of serum protein with anticancer drugs. It can derive from the influence of
the drug on protein conformation or binding close to binding site of anticancer drug. Aspirin, vitB2 and
warfarin bind to IIA subdomain leading to partial blocking of the ruthenium binding site in HSA. |
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