The Effect of Fused 12-Membered Nickel Metallacrowns
on DNA and their Antibacterial Activity |
| |
| Authors: | I Tsivikas M Alexiou A A Pantazaki C Dendrinou-Samara D A Kyriakidis D P Kessissoglou |
| |
| Institution: | 1. Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece.;2. Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece, |
| |
| Abstract: | The synthesis, characterization and the biological study of a series of Ni(ll)2(carboxylato)2 12-
MCNi(II)N(shi)2(pko)2-4]12-MCNi(ii)N(sh03(pko)-4] (CH3OH)3(H3O) fused 12-membered metallacrowns with 10 metal ions and commercial available herbicides or anti-inflammatory drugs as carboxylato ligands are
reported. All the compounds have a mixed ligand composition with salicylhydroxamic acid and di-2-pyridylketonoxime
as chelate agents. The compounds construct metallacrown cores {12-MCNi(n)N(sj02(pko)2-4]12-MCNi(ll)N(shO3(pko)-4]}2+ following the pattern -Ni-O-N-]4. The neutral decanuclear Ni(II)(A)]212-MCNi(II)N(shi)2(pko)2-4]12-MCNi(II)N(pko)3(pko)-4] fused metallacrown, consists of two 12-MCM(ox)N(ligand)-4] units the {Ni(ll)(A)12-MCNi(II)N(shi)2(pko)2-4]} and {Ni(II)(A)12-MCNi(II)N(shi)3(pko)-4]} with 1+ and 1- charge, respectively. Each metallacrown unit has four ring Ni(II) ions and one additional encapsulated Ni(II) ion in planar arrangement. The anionic unit is bonded with cationic one creating binuclear moieties. The herbicide or antiiflammatory carboxylato ligands are bridging the central octahedral nickel atom with a ring metal ion
in a bindetate fashion. The effect on DNA and their antibacterial activity was examined. The changes in the
mobility can be attributed to the altered structures of the pDNA treated with Ni(II) complexes. Evaluating the
data of the antibacterial activity of the compounds tested, we can conclude that nickel complexes present
strong antibacterial activity. |
| |
| Keywords: | |
|
|
