A database for G proteins and their interaction with GPCRs |
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Authors: | Antigoni L Elefsinioti Pantelis G Bagos Ioannis C Spyropoulos Stavros J Hamodrakas |
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Affiliation: | (1) Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Athens, 157 01, Greece |
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Abstract: | Background G protein-coupled receptors (GPCRs) transduce signals from extracellular space into the cell, through their interaction with G proteins, which act as switches forming hetero-trimers composed of different subunits (α,β,γ). The α subunit of the G protein is responsible for the recognition of a given GPCR. Whereas specialised resources for GPCRs, and other groups of receptors, are already available, currently, there is no publicly available database focusing on G Proteins and containing information about their coupling specificity with their respective receptors. |
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