Statistical properties of the dichotomous noise generated in biochemical processes |
| |
Authors: | Michał Kurzyński |
| |
Institution: | (1) Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznań, Poland |
| |
Abstract: | Dichotomous noise detected with the help of various single-molecule techniques convincingly reveals the actual occurrence
of a multitude of conformational substates composing the native state of proteins. The nature of the stochastic dynamics of
transitions between these substates is determined by the particular statistical properties of the noise observed. These involve
nonexponential and possibly oscillatory time decay of the second order autocorrelation function, its relation to the third
order autocorrelation function, and a relationship to dwell-time distribution densities and their correlations. Processes
gated by specific conformational substates are distinguished from those with fluctuating barriers. This study throws light
on the intriguing matter of the possibility of multiple stepping of the myosin motor along the actin filament per ATP molecule
hydrolyzed.
Paper authored by participants of the international conference: International Workshop on Ionic Channels, Szczyrk, Poland,
May 27 – June 01, 2007. Publication cost was covered by the organisers of this meeting. |
| |
Keywords: | Single-molecule techniques Time autocorrelation functions Dwell-time distribution densities Molecular gear |
本文献已被 PubMed SpringerLink 等数据库收录! |
|