Platelet aggregation is inhibited by long chain acyl-CoA |
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Authors: | I Lascu B Edwards M P Cucuianu D W Deamer |
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Institution: | Department of Biochemistry, Medical and Pharmaceutical Institute, Cluj-Napoca, Romania. |
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Abstract: | Oleoyl coenzyme A and other acyl-CoA derivatives inhibited ADP or thrombin-induced aggregation of platelets. Arachidonic acid-induced aggregation was also inhibited, but not the slower aggregation caused by 1-oleoyl-2-acetylglycerol or tetradecanoyl-phorbol-13-acetate. Coenzyme A and free fatty acids had little or no effect, and transfer of labeled oleate from oleoyl Co-A to other lipid classes was not detected. Because acyl Co-A compounds have recently been shown to modulate protein kinase C activity, acyl Co-A may provide a useful tool for investigating activation sequences in platelets and other membranes. |
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