Effects of prostaglandin E1 and indomethacin on fetal and neonatal lamb mesenteric artery responses to norepinephrine |
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| Authors: | Steven M Yabek Barry P Avner |
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| Institution: | Departments of Pediatrics and Pharmacology, University of New Mexico, School of Medicine, Albuquerque, USA 87131 |
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| Abstract: | The effects of prostaglandin E1 (PGE1) and indomethacin on isolated fetal and neonatal lamb mesenteric artery responses to norepinephrine were investigated. PGE1 (1.5μM) significantly reduced vasoconstriction responses to 0.5 to 5μM norepinephrine. Indomethacin (1μM) markedly potentiated the constrictor effects of 0.5 to 10μM norepinephrine. PGE1 prevented the potentiating effect of indomethacin. Neither PGE1 nor indomethacin altered basal muscle tension. These results suggest that endogenous PGs modify adrenergic responses in the isolated mesenteric arteries of preterm and newborn lambs. |
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| Keywords: | Correspondence to: Steven M Yabek M D Department of Pediatrics University of New Mexico School of Medicine Albuquerque New Mexico 87131 USA |
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