Induction of tumour necrosis factor alpha in experimental animals treated with hepatotoxicants. |
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| Authors: | A Roy G R Soni R M Kolhapure K Banerjee P S Patki |
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| Affiliation: | National Institute of Virology, Pune, India. |
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| Abstract: | Administrations of hepatotoxicants namely carbon tetrachloride (CCl4:0.4 ml in 1.2 ml of liquid paraffin) and ANIT (1 ml of 1.5% solution in liquid paraffin) in Charles foster rats (force fed) and D-galactosamine (8 mg in water per swiss albino mouse, ip) induce the release of TNF-alpha in case of CCl4 and D-galactosamine. High TNF-alpha level was observed up to 48 hr in CCl4 and up to 24 hr in D-galactosamine treated animals. Elevated levels of biochemical like ALP and SGPT are also recorded. TNF-alpha level can be measured of tissue damage and prognosis in case of hepatitis. |
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