MicroRNAs,stem cells and cancer stem cells |
| |
Authors: | Minal Garg |
| |
Institution: | Minal Garg, Department of Biochemistry, University of Lucknow, Lucknow 226007, India |
| |
Abstract: | This review discusses the various regulatory charac-teristics of microRNAs that are capable of generating widespread changes in gene expression via post translational repression of many mRNA targets and control self-renewal, differentiation and division of cells. It controls the stem cell functions by controlling a wide range of pathological and physiological processes, including development, differentiation, cellular proliferation, programmed cell death, oncogenesis and metastasis. Through either mRNA cleavage or translational repression, miRNAs alter the expression of their cognate target genes; thereby modulating cellular pathways that affect the normal functions of stem cells, turning them into cancer stem cells, a likely cause of relapse in cancer patients. This present review further emphasizes the recent discoveries on the functional analysis of miRNAs in cancer metastasis and implications on miRNA based therapy using miRNA replacement or anti-miRNA technologies in specific cancer stem cells that are required to establish their efficacy in controlling tumorigenic potential and safe therapeutics. |
| |
Keywords: | Stem cell functions Cancer stem cells Cellular pathways miRNA oncomiR Tumor suppressor miRNAs miRNA based therapeutics |
本文献已被 CNKI 等数据库收录! |
| 点击此处可从《World journal of stem cells》浏览原始摘要信息 |
|