Calcium-activated neutral protease and its endogenous inhibitor Activation at the cell membrane and biological function |
| |
Authors: | Koichi Suzuki Shinobu Imajoh Yasufumi Emori Hiroshi Kawasaki Yasufumi Minami Shigeo Ohno |
| |
Affiliation: | Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Honkomagome, Bunkyo-ku, Tokyo 113, Japan |
| |
Abstract: | The structures of calcium-activated neutral protease (CANP) and its endogenous inhibitor elucidated recently have revealed novel features with respect to their structure-function relationship and enzyme activity regulation. The protease is regarded as a proenzyme which can be activated at the cell membrane in the presence of Ca2+ and phospholipid, and presumably regulates the functions of proteins, especially membrane-associated proteins, by limited proteolysis. Protein kinase C is hydrolysed and activated by CANP at the cell membrane to a cofactor-independent form. These results are reviewed and the possible involvement of CANP in signal transduction is discussed. |
| |
Keywords: | Ca2+-dependent protease Enzyme inhibitor Proenzyme activation Protein kinase C |
本文献已被 ScienceDirect 等数据库收录! |