Choreography of recombination proteins during the DNA damage response |
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Authors: | Michael Lisby Rodney Rothstein |
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Affiliation: | aDepartment of Biology, University of Copenhagen, Ole Maaloees Vej 5, DK-2200 Copenhagen N, Denmark;bDepartment of Genetics & Development, Columbia University Medical Center, 701 West 168th Street, New York, NY 10032-2704, United States |
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Abstract: | Genome integrity is frequently challenged by DNA lesions from both endogenous and exogenous sources. A single DNA double-strand break (DSB) is lethal if unrepaired and may lead to loss of heterozygosity, mutations, deletions, genomic rearrangements and chromosome loss if repaired improperly. Such genetic alterations are the main causes of cancer and other genetic diseases. Consequently, DNA double-strand break repair (DSBR) is an important process in all living organisms. DSBR is also the driving mechanism in most strategies of gene targeting, which has applications in both genetic and clinical research. Here we review the cell biological response to DSBs in mitotically growing cells with an emphasis on homologous recombination pathways in yeast Saccharomyces cerevisiae and in mammalian cells. |
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Keywords: | Homologous recombination Foci DNA double-strand break repair Saccharomyces cerevisiae Mammalian |
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