Genetic Localization of Foraging (For): A Major Gene for Larval Behavior in Drosophila Melanogaster |
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Authors: | J. S. de-Belle A. J. Hilliker M. B. Sokolowski |
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Affiliation: | Department of Biology, York University, North York, Ontario, Canada. |
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Abstract: | Localizing genes for quantitative traits by conventional recombination mapping is a formidable challenge because environmental variation, minor genes, and genetic markers have modifying effects on continuously varying phenotypes. We describe "lethal tagging," a method used in conjunction with deficiency mapping for localizing major genes associated with quantitative traits. Rover/sitter is a naturally occurring larval foraging polymorphism in Drosophila melanogaster which has a polygenic pattern of inheritance comprised of a single major gene (foraging) and minor modifier genes. We have successfully localized the lethal tagged foraging (for, 2-10) gene by deficiency mapping to 24A3-C5 on the polytene chromosome map. |
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