Modifiers of notch transcriptional activity identified by genome-wide RNAi |
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| Authors: | Philippos Mourikis Robert J Lake Christopher B Firnhaber Brian S DeDecker |
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| Affiliation: | (1) Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA;(2) Stem Cells & Development, Department of Developmental Biology, Pasteur Institute, CNRS URA 2578, Paris, France;(3) Epigenetics and Progenitor Cells Keystone Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA |
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| Abstract: | Background The Notch signaling pathway regulates a diverse array of developmental processes, and aberrant Notch signaling can lead to diseases, including cancer. To obtain a more comprehensive understanding of the genetic network that integrates into Notch signaling, we performed a genome-wide RNAi screen in Drosophila cell culture to identify genes that modify Notch-dependent transcription. |
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