| 基于受体的药物高通量筛选研究进展 |
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| 引用本文： | 冯璐璐,赵霞霞,李发荣. 基于受体的药物高通量筛选研究进展[J]. 生命科学, 2009, 0(3): 408-411 |
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| 作者姓名： | 冯璐璐 赵霞霞 李发荣 |
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| 作者单位： | 陕西师范大学生命科学学院,西安710062 |
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| 基金项目： | 陕西省科技攻关项目（2006K16-G2（3））. |
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| 摘 要： | 受体是药物筛选的重要靶标，基于受体的药物高通量筛选是药物筛选的主要类型之一。本文根据受体作用原理，按照检测对象的不同，从直接与间接检测的角度，将基于受体的药物高通量筛选进行了分类，总结了基于受体的几种不同的药物筛选模型，并简要介绍了高通量筛选技术在中药研究中的应用，对药物筛选的发展进行了展望。
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| 关 键 词： | 受体模型 高通量筛选 中药研究 |
Progress of high-throughput drug screening based on the receptor model |
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| FENG Lu-lu,ZHAO Xia-xia,LI Fa-rong. Progress of high-throughput drug screening based on the receptor model[J]. Chinese Bulletin of Life Sciences, 2009, 0(3): 408-411 |
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| Authors: | FENG Lu-lu ZHAO Xia-xia LI Fa-rong |
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| Affiliation: | (College of Life Sciences, Shaanxi Normal University, Xi＇an 710062, China) |
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| Abstract: | The receptor is attractive as an important target for drug screening. Receptor-based high-throughput screening is one of the main techniques in modern drug discovery. According to the mechanism of drugreceptor interaction and different object of detection, this paper reviews the classification of the high-throughput screening models based on the receptor, simply introduces the application of high-throughput screening technique in traditional Chinese medicine research, and discusses its future development. |
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| Keywords: | receptor model high-throughput screening Chinese medicine research |
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