Identification of collagen alpha1(I) trimer and normal type I collagen in a polyoma virus-induced mouse tumor. |
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| Authors: | L Moro B D Smith |
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| Affiliation: | National Institute of Dental Research, Bethesda, Maryland 20014 U.S.A. |
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| Abstract: | A bone- and cartilage-forming mouse tumor, induced by transforming salivary epithelial cells with polyoma virus, contained large quantities of collagen. Two types of collagen molecules were isolated which had different solubilities in salt. One was type I collagen with a chain composition [α1(I)]2 α2 and the other was an unusual form of type I collagen with a chain composition [α1(I)]3. This would appear to be the first in vivo demonstration of α1 type I trimer. |
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