Increased erythritol production in fed-batch cultures of Torula sp. by controlling glucose concentration |
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Authors: | D-K Oh C-H Cho J-K Lee S-Y Kim |
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Institution: | (1) Department of Bioscience and Biotechnology, Sejong University, 98 Kunja-Dong, Kwangjin-Ku, Seoul 143-747, South Korea, KR;(2) BioNgene, 307-1 Songsan-Ri, Yangkam-Myun, Hwasung-Kun, Kyongki-Do 445-930, South Korea, KR |
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Abstract: | The effect of glucose concentration on erythritol production by Torula sp. was investigated. The maximum volumetric productivity of erythritol was obtained at an initial glucose concentration
of 300 g l−1 in batch culture. The volumetric productivity was maximal at a controlled glucose concentration of 225 g l−1, reducing the lag time of the erythritol production. A fed-batch culture was established with an initial glucose concentration
of 300 g l−1 and with a controlled glucose concentration of 225 g l−1 in medium containing phytic acid as a phosphate source. In this fed-batch culture, a final erythritol production of 192 g
l−1 was obtained from 400 g l−1 glucose in 88 h. This corresponded to a volumetric productivity of 2.26 g l−1 h−1 and a 48% yield. Journal of Industrial Microbiology & Biotechnology (2001) 26, 248–252.
Received 26 September 2000/ Accepted in revised form 16 January 2001 |
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Keywords: | : erythritol Torula sp fed-batch culture glucose concentration phytic acid production rate |
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