Exploration of the antidepressant potential of iprindole. |
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Authors: | I Sanghvi H Geyer S Gershon |
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Institution: | Neuropsychopharmacology Research Unit Department of Psychiatry New York University Medical Center 550 First Avenue, New York, N.Y. 10016, USA |
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Abstract: | Iprindole, a tricyclic indole compound with an antidepressant activity was evaluated in an animal test model. In this test a potential antidepressant agent should potentiate the behavioral and cardiovascular effects of yohimbine, a naturally occurring indole alkaloid, in conscious dogs. For comparison, imipramine, a standard antidepressant drug was used. Iprindole was tested at a dose of 3, 9, and 15 mg per kg. It potentiated the behavioral and cardiovascular effects of yohimbine at a dose of 9 mg per kg. Iprindole failed to potentiate norepinephrine response in dogs; similar observations are reported in man. The results further confirm the validity of the present test for evaluation of potential antidepressant agents in conscious dog. |
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