Daily zinc supplementation effect on zinc deficiency in rats during prolonged restriction of motor activity |
| |
Authors: | Yan G Zorbas Yuri N Yaroshenko Nikolai K Kuznetsov Alexei L Ivamov |
| |
Institution: | (1) Hypokinetic Physiol. Lab., Odos Agias Sophias 81, GR-162 32 Athens, Greece;(2) Kosmic Biology Inst., Krasno Selo, 1404 Sofia, Bulgaria |
| |
Abstract: | The objective of this investigation was to evaluate the effect of 47 mg zinc supplementation on deficiency of zinc in rats
during 98 d of restriction of motor activity (hypokinesia), which appeared by higher plasma zinc concentration.
One Hundred 13-week-old Sprague-Dawley male rats weighing 360–390 g were used to perform the studies: They were equally divided
into four groups: 1. Unsupplemented control animals (UCA); 2. Unsupplemented hypokinetic animals (UHA); 3. Supplemented control
animals (SCA); and 4. Supplemented hypokinetic animals (SHA). For the simulation of the effect of hypokinesia (HK), the UHA
and SHA were kept in small individual cages made of wood, which restricted their movements in all directions without hindering
food and water intake. The SCA and SHA received daily with their food an additional amount of zinc.
Before and during the experimental period of 98 d, plasma, urinary and fecal zinc, balance of zinc, food intake, and body
weight were determined at different intervals. In the SHA and UHA, the concentration of zinc in plasma, and the elimination
of zinc in urine and feces increased significantly when compared with the SCA and UCA, whereas the balance of zinc was negative.
The body weight and food intake decreased significantly in the SHA and UHA when compared with the SCA and UCA. The increased
plasma concentration of zinc in both the SHA and UHA groups was in contrast to the observed hypozincnemia during prolonged
immobilization as during prolonged hospitalization. This reaction suggests that there may be some other mechanisms that are
affecting the process of control and regulation of zinc metabolism during prolonged HK.
It was concluded that exposure to prolonged restriction of motor activity of rats induces significant increases in plasma
concentration, fecal and urinary elimination of zinc in the presence of negative zinc balance and regardless the daily intake
of large amounts of zinc with their food, leading to zinc deficiency. |
| |
Keywords: | Zinc deficiency zinc supplementation hypokinesia rats |
本文献已被 SpringerLink 等数据库收录! |
|