Host Range Restriction of Epstein-Barr Virus and Related Lymphocryptoviruses |
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| Authors: | Janine Mühe Fred Wang |
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| Affiliation: | Department of Medicine, Brigham & Women''s Hospital, Harvard Medical School, Boston, Massachusetts, and Department of Molecular Biology & Immunobiology, Harvard Medical School, Boston, Massachusetts, USA |
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| Abstract: | Epstein-Barr-related herpesviruses, or lymphocryptoviruses (LCV), naturally infect humans and nonhuman primates (NHP), but their host range is not well characterized. Using LCV and B cells from multiple species of Hominidae and Cercopithecidae, we show that LCV can immortalize B cells from some nonnative species but that growth transformation is restricted to B cells from their own family of hominoids or Old World NHP, suggesting a high degree of LCV adaptation to their natural primate host. |
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