Increased risk of breast cancer in women with false-positive test: The role of misclassification |
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| Affiliation: | 1. Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, DK-1014 Copenhagen, Denmark;2. Department of Radiology, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark;1. CEMDRX, Department of Physics, University of Coimbra, Rua Larga, P-3004-516 Coimbra, Portugal;2. Advanced Materials Laboratory, ETSIIAA, Universidad de Valladolid, Avenida de Madrid 44, 34004 Palencia, Spain;3. MALTA Consolider Team, and Department of Fundamental and Experimental Physics, Electronics and Systems, Universidad de La Laguna, E-38200 San Cristóbal de La Laguna, Santa Cruz de Tenerife, Tenerife, Spain;4. Higher Technical School of Telecommunications Engineering, Universidad de Valladolid, Campus Miguel Delibes, Paseo Belén 15, 47011 Valladolid, Spain;1. Family and Community Medicine, 1015 Walnut St. Suite 401, Philadelphia PA, 19107, USA;2. Sydney Kimmel Medical College, 1025 Walnut St #100, Philadelphia, PA 19107, USA;1. Department of Computer Architecture and Technology, University of Girona, Girona, Spain;2. UDIAT-Centre Diagnòstic, Corporació Parc Taulí, 08208 Sabadell, Spain;3. Department of Computer Science, Aberystwyth University, Aberystwyth SY23 3DB, UK |
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| Abstract: | IntroductionStudies have shown that women with a false-positive result from mammography screening have an excess risk for breast cancer compared with women who only have negative results. We aimed to assess the excess risk of cancer after a false-positive result excluding cases of misclassification, i.e. women who were actually false-negatives instead of false-positives.MethodWe used data from the Copenhagen Mammography Screening Programme, Denmark. The study population was the 295 women, out of 4743 recalled women from a total of 58,003 participants, with a false-positive test during the screening period 1991–2005 and who later developed breast cancer. Cancers that developed in the same location as the finding that initially caused the recall was studied in-depth in order to establish whether there had been misclassification.ResultsSeventy-two cases were found to be misclassified. When the women with misclassified tests had been excluded, there was an excess risk of breast cancer of 27% (RR = 1.27, 95% confidence interval (CI), 1.11–1.46) among the women with a false-positive test compared to women with only negative tests. Women with a false-positive test determined at assessment had an excess risk of 27%, while false-positives determined at surgery had an excess risk of 30%.ConclusionsThe results indicate that the increased risk is not explained only by misclassification. The excess risk remains for false-positives determined at assessment as well as at surgery, which favours some biological susceptibility. Further research into the true excess risk of false positives is warranted. |
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| Keywords: | Breast cancer Screening Mammography False-positive Misclassification |
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