Structural analysis of five new monosialylated oligosaccharides from human milk. |
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| Authors: | G Gr?nberg P Lipniunas T Lundgren F Lindh B Nilsson |
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| Affiliation: | BioCarb Technology AB, Lund, Sweden. |
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| Abstract: | The total monosialylated oligosaccharide fraction from pooled human milk was isolated by gel filtration and ion-exchange chromatography. Further separation by HPLC using a mobile phase containing an ion-pairing reagent of triethylamine gave five new monosialylated oligosaccharides. Structural analysis was carried out by chemical analyses, fast atom bombardment mass spectrometry, and 500-MHz NMR spectroscopy. Combined structural data revealed the following new structures: [formula: see text] |
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