| 胞外ATP在男性生殖道中的作用 |
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| 引用本文： | Zhou WL,Zuo WL,Ruan YC,Wang Z,DU JY,Xiong Y,Chan HC. 胞外ATP在男性生殖道中的作用[J]. 生理学报, 2007, 59(4): 487-494 |
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| 作者姓名： | Zhou WL Zuo WL Ruan YC Wang Z DU JY Xiong Y Chan HC |
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| 作者单位： | 中山大学生命科学学院生理学教研室,广州,510275;香港中文大学医学院生理学系上皮细胞生物学研究中心,香港 |
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| 摘 要： | 胞外ATP除了能广泛作为神经递质外,还被认为是一种旁分泌或自分泌因子。ATP从男性生殖道中的精子或上皮细胞中释放,在调节各种生殖生理功能中起多种作用。本文综述了ATP调节附睾上皮细胞阴离子分泌的信号通路,阐述了ATP对依赖上皮细胞的输精管平滑肌收缩的调节机制,讨论了ATP在男性生殖道中的功能和作用。
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| 关 键 词： | ATP 附睾 输精管 上皮分泌 平滑肌收缩 |
| 修稿时间： | 2007-07-03 |
The role of extracellular ATP in the male reproductive tract |
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| Zhou Wen-Liang,Zuo Wu-Lin,Ruan Ye-Chun,Wang Zhe,DU Jian-Yang,Xiong Yuan,Chan Hsiao-Chang. The role of extracellular ATP in the male reproductive tract[J]. Acta Physiologica Sinica, 2007, 59(4): 487-494 |
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| Authors: | Zhou Wen-Liang Zuo Wu-Lin Ruan Ye-Chun Wang Zhe DU Jian-Yang Xiong Yuan Chan Hsiao-Chang |
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| Affiliation: | Department of Physiology, School of Life Science, Sun Yat-Sen University, Guangzhou 510275, China; ;Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China |
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| Abstract: | In addition to its well established role as a neurotransmitter, extracellular ATP has been considered as a paracrine/autocrine factor, either released from sperm or epithelial cells, in the male reproductive tract and shown to play a versatile role in modulating various reproductive functions. This review summarizes the signal pathways through which ATP induces anion secretion by the epithelia of the epididymis, as well as its epithelium-dependent modulation of smooth muscle contraction of the vas deferens. Finally, the overall role of ATP in coordinating various reproductive events in the male genital tract is discussed. |
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| Keywords: | ATP ATP epididymis vas deferens epithelial secretion smooth muscle contraction |
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