Cytologic findings of epithelioid angiosarcoma of the thyroid. A case report |
| |
Authors: | Lin Oscar Gerhard Rene Coelho Siqueira Sheila Aparecida de Castro Ines Vieira |
| |
Affiliation: | Department of Anatomic Pathology, Hospital das Clinicas da Faculdade de Medicina da Universidade de S?o Paulo, S?o Paulo, SP, Brazil. lino@mskcc.org |
| |
Abstract: | BACKGROUND: Angiosarcoma of the thyroid is a rare and aggressive tumor and occurs mainly in patients from central Europe, especially the alpine region. The fine needle aspiration findings of a keratin-positive epithelioid angiosarcoma of the thyroid occurring in a nonmountainous area in South America is described. CASE: A 65-year-old male from S?o Paulo, Brazil, presented with a mass in the anterior part of the neck with progressive enlargement for three months. The cytologic findings on the fine needle aspirate were a cellular smear composed of single cells and small clusters of neoplastic cells, oval and round. Cell borders were indistinct, and the cytoplasm was vacuolated. The nuclei were eccentrically located, with irregular nuclear membranes; single, prominent nucleoli; and a coarse chromatin pattern. Features suggestive of intracytoplasmic lumens were identified. Open surgical biopsy demonstrated a tumor infiltrating the thyroid gland and composed of large, round, atypical epithelioid cells lining vascular spaces. These neoplastic cells were immunoreactive for AE1:AE3, CK7, vimentin, CD31 and factor VIII. CONCLUSION: Epithelioid angiosarcoma should be considered in the differential diagnosis of epithelioid neoplasms of the thyroid. An immunohistochemical panel should include vascular markers even in the presence of immunoreactivity for epithelial markers. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|