Realignment of signal processing within a sensory brainstem nucleus as brain temperature declines in the Syrian hamster, a hibernating species |
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Authors: | Sekizawa Shin-Ichi Horowitz John M Horwitz Barbara A Chen Chao-Yin |
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Institution: | (1) Department of Pharmacology, University of California Davis, GBSF 3617, 451 Health Sciences Drive, Davis, CA 95616, USA;(2) Department of Neurobiology, Physiology, and Behavior, University of California Davis, Davis, CA 95616, USA; |
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Abstract: | Crucial for survival, the central nervous system must reliably process sensory information over all stages of a hibernation
bout to ensure homeostatic regulation is maintained and well-matched to dramatically altered behavioral states. Comparing
neural responses in the nucleus tractus solitarius of rats and euthermic Syrian hamsters, we tested the hypothesis that hamster
neurons have adaptations sustaining signal processing while conserving energy. Using patch-clamp techniques, we classified
second-order neurons in the nucleus as rapid-onset or delayed-onset spiking phenotypes based on their spiking onset to a depolarizing
pulse (following a −80 mV prepulse). As temperature decreased from 33 to 15°C, the excitability of all neurons decreased.
However, hamster rapid-onset spiking neurons had the highest spiking response and shortest action potential width at every
temperature, while hamster delayed-onset spiking neurons had the most negative resting membrane potential. The frequency of
spontaneous excitatory postsynaptic currents in both phenotypes decreased as temperature decreased, yet the amplitudes of
tractus solitarius stimulation-evoked currents were greater in hamsters than in rats regardless of phenotype and temperature.
Changes were significant (P < 0.05), supporting our hypothesis by showing that, as temperature falls, rapid-onset neurons contribute more to signal processing
but less to energy conservation than do delayed-onset neurons. |
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