Two-dimensional difference gel electrophoresis (DIGE) analysis of sera from visceral leishmaniasis patients |
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| Authors: | Lokesh A Rukmangadachar Jitender Kataria Gururao Hariprasad Jyotish C Samantaray Alagiri Srinivasan |
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| Institution: | (1) Department of Biophysics, All India Institute of Medical Sciences, New Delhi, 110029, India;(2) Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, 110029, India;(3) Department of Microbiology, All India Institute of Medical Sciences, New Delhi, 110029, India |
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| Abstract: | Introduction Visceral leishmaniasis is a parasitic infection caused by Lesihmania donovani complex and transmitted by the bite of the phlebotomine sand fly. It is an endemic disease in many developing countries with more than 90% of the cases occurring in Bangladesh,
India, Nepal, Sudan, Ethiopia and Brazil. The disease is fatal if untreated. The disease is conventionally diagnosed by demonstrating
the intracellular parasite in bone marrow or splenic aspirates. This study was carried out to discover differentially expressed
proteins which could be potential biomarkers. |
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