Decreased binding of insulin to its receptors in rats with hormone induced insulin resistance |
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| Authors: | I D Goldfine C R Kahn D M Neville J Roth M M Garrison R W Bates |
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| Institution: | 1. Diabetes Section, Clinical Endocrinology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014 USA;2. Section on Biophysical Chemistry, Laboratory of Neurochemistry, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20014 USA;3. Laboratory of Nutrition and Endocrinology, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014 USA |
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| Abstract: | Insulin and glucagon receptor binding was studied in purified liver membranes from rats made insulin resistant by implantation of an MtT pituitary tumor which secretes growth hormone, prolactin, and ACTH. Insulin binding to its receptors was decreased and correlated with the degree of insulin resistance. In contrast, binding of glucagon to its receptors was unchanged. |
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