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Tumor regression induced by defined microbial components in an oil-in-water emulsion is mediated through their binding to oil droplets |
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| Authors: | C A McLaughlin E E Ribi M B Goren R Toubiana |
| Institution: | (1) Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, 59840 Hamilton, Montana, USA;(2) National Jewish Hospital and University of Colorado School of Medicine, 80206 Denver, Colorado, USA;(3) CNRS Institute de Chimie des Substances Naturelles, Gif-sur-Yvette, France |
| Abstract: | Summary Oil-in-water emulsions containing aqueous-soluble glycolipids combined with synthetic or naturally occurring fatty acid esters derived from mycobacteria were found to be potent tumor regressive preparations. An apparent mode of action of these fatty acid esters in regression of treated tumors was shown to be that of binding glycolipids to oil droplets. A model is presented. |
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