A third human CALC (pseudo)gene on chromosome 11 |
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| Authors: | J W H?ppener P H Steenbergh J Zandberg G J Adema A H Geurts van Kessel C J Lips H S Jansz |
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| Institution: | Institute of Molecular Biology, State University of Utrecht, The Netherlands. |
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| Abstract: | A genomic locus in man (CALC-III) containing nucleotide sequences highly homologous to both exon 2 and exon 3 of the CALC-I and -II genes, is described in this paper. The CALC-I gene produces calcitonin (CT) (encoded by exon 4) or calcitonin gene-related peptide (CGRP) (encoded by exon 5) in a tissue-specific fashion. The CALC-II gene produces a second human CGRP, but probably not a second CT. The CALC-III gene does not seem to encode a CT- or CGRP-related polypeptide hormone and is probably a pseudogene. Like the other two CALC genes, the CALC-III gene is located on human chromosome 11. |
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