| 诱导多能干细胞研究进展 |
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| 引用本文： | 罗庆,宋关斌,袁琳.诱导多能干细胞研究进展[J].生物技术通报,2009(7). |
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| 作者姓名： | 罗庆 宋关斌 袁琳 |
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| 作者单位： | 重庆大学生物工程学院,生物流变科学与技术教育部重点实验室,重庆,400044 |
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| 基金项目： | 国家自然科学基金，重庆大学研究生科技创新基金 |
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| 摘 要： | 用4个外源基因从完全分化的人成纤维细胞诱导获得了具有胚胎干细胞特性的诱导多能干细胞(iPS细胞),成功逆转了细胞单向发育的规则,取得了细胞重编程和干细胞研究中的重大突破.围绕c-Myc基因和基因载体、诱导效率和外源基因替代因子等方面的研究内容,综述了自2007年人iPS细胞构建至今,国内外在改进iPS细胞诱导方法上的主要研究进展.
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| 关 键 词： | 诱导多能干细胞 重编程 肿瘤形成 诱导效率 替代因子 |
Research Progress of Induced Pluripotent Stem Cell |
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| Luo Qing,Song Guanbin,Yuan Lin.Research Progress of Induced Pluripotent Stem Cell[J].Biotechnology Bulletin,2009(7). |
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| Authors: | Luo Qing Song Guanbin Yuan Lin |
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| Institution: | Luo Qing Song Guanbin Yuan Lin (College of Bioengineering,Chongqing University,Key Laboratory of Biorheological Science and Technology,Ministry of Education,Chongqing 400044) |
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| Abstract: | The findings of induced pluripotent stem cells (iPS cells) reserved the developmental arrow of cells and considered a great breakthrough of reprogramming and stem cell researches. The research progress of the method improvement of iPS induction were reviewed and three aspects of researches including c-Myc gene and vectors, inductive efficiency as well as candidates for exogenous gene replacement were focused. |
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| Keywords: | Lnduced pluripotent stem cell Reprogram Tumorgenesis Inductive efficiency Replacement factor |
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