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Dinuclear macrocyclic polyamine zinc(II) complexes linked with flexible spacers: synthesis, characterization, and DNA cleavage |
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| Authors: | Peng Wei Liu Pei-Yan Jiang Ning Lin Hong-Hui Zhang Guo-Lin Liu Yi Yu Xiao-Qi |
| Institution: | a Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, PR China b College of Life Science, Sichuan University, Chengdu 610064, PR China c Chengdu Institute of Biology, The Chinese Academy of Sciences, Chengdu 610041, PR China |
| Abstract: | Dinuclear macrocyclic polyamine zinc(II) complexes, which have two cyclen groups linked by flexible spacers, have been synthesized as DNA cleavage agents. The structures of these new dinuclear complexes are consistent with the data obtained from elemental analysis, MS and 1H NMR spectroscopy. The catalytic activity of these dinuclear complexes on DNA cleavage was studied. The results showed that the dinuclear zinc(II) complexes can catalyze the cleavage of supercoiled DNA (pUC 19 plasmid DNA) (Form I) under physiological conditions to produce selectively nicked DNA (Form II). |
| Keywords: | 1 4 7 10-Tetraazacyclododecane (cyclen) Macrocyclic polyamine Dinuclear complexes pUC 19 DNA Cleavage |
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