Chromanol derivatives--a novel class of CETP inhibitors |
| |
Authors: | Vakalopoulos Alexandros Schmeck Carsten Thutewohl Michael Li Volkhart Bischoff Hilmar Lustig Klemens Weber Olaf Paulsen Holger Elias Harry |
| |
Affiliation: | Bayer HealthCare AG, Bayer Schering Pharma, Global Drug Discovery, D-42096 Wuppertal, Germany. alexandros.vakalopoulos@bayer.com |
| |
Abstract: | Based on our former development candidate BAY 38-1315, optimization efforts led to the discovery of a novel chemical class of orally active cholesteryl ester transfer protein (CETP) inhibitors. The chromanol derivative 19b is a highly potent CETP inhibitor with favorable pharmacokinetic properties suitable for clinical studies. Chemical process optimization furnished a robust synthesis for a kilogram-scale process. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|