Increase of chondroitin 4-sulfate concentration in the endochondral ossification cartilage of normal dogs |
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Authors: | R C Harab P A Mour?o |
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Institution: | Departamento de Bioquímica, Universidade Federal do Rio de Janeiro, Brasil. |
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Abstract: | The absolute concentrations of chondroitin 4- and 6-sulfate are compared in articular and endochondral ossification cartilage from normal dogs. In newborn dogs, the absolute concentration of chondroitin 4-sulfate decreases nearly 3-fold from the deeper endochondral ossification cartilage to the articular surface, whereas that of chondroitin 6-sulfate does not change. In cartilage from the articular surface of the epiphysis in adults, where the ossification process is complete, the concentration of chondroitin 4-sulfate is also low. These observations suggest that chondroitin 4-sulfate may be important in the ossification process. The pathogenesis of heritable disorders involving the sulfation of chondroitin sulfate is discussed in view of these findings. |
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