Metabolic fingerprinting of blood plasma from patients with prostate cancer |
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| Authors: | P. G. Lokhov M. I. Dashtiev L. V. Bondartsov A. V. Lisitsa S. A. Moshkovskii A. I. Archakov |
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| Affiliation: | 1.Institute of Biomedical Chemistry,Russian Academy of Medical Sciences,Moscow,Russia |
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| Abstract: | Application of blood plasma metabolites fingerprinting for the diagnostic of the 2nd stage of prostate cancer has been investigated. The diagnostic sensitivity (95%), specificity (96.7%) and accuracy (95.7%) of the metabolic fingerprinting were much higher then those for the ELISA PSA test (35%, 83.3% and 51.7%, respectively) performed for the same patients. Area under the ROC curve (0.994) suggests that the proposed approach based on the metabolic fingerprinting is effective and applicable in clinical practice. |
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