Bone resorbing activities of 24-hydroxy stereoisomers of 24-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3.期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Bone resorbing activities of 24-hydroxy stereoisomers of 24-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3.

Authors:	P H Stern H F DeLuca N Ikekawa

Affiliation:	Department of Pharmacology, Northwestern Univ. Medical School Chicago, Ill. 60611, U.S.A.;Department of Biochemistry, University of Wisconsin-Madison Madison, Wisconsin 53706, U.S.A.;Laboratory of Chemistry for Natural Products Tokyo Institute for Technology, Meguroko, Tokyo, Japan

Abstract:	R and S isomers of 24-OH-D₃ and 24,25-(OH)₂D₃ were tested for their effects on bone resorption $in vitro$ . 24(R), 25-(OH)₂D₃ was more active than 24(S),25-(OH)₂D₃. Likewise, 24(R)-OH-D₃ was more active than 24(S)-OH-D₃. The bone resorbing activity of 24(R)-OH-D₃ was equivalent to that of 25-OH-D₃; 24(R),25-(OH)₂D₃ was somewhat less potent. The results indicate that there is discrimination between the isomers of these compounds at the level of the responding tissue.

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