| 青钱柳多糖对人胃癌MGC_803细胞生长的影响 |
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| 引用本文： | 韩澄,聂少平,黄丹菲,陈一睛,谢建华,谢明勇.青钱柳多糖对人胃癌MGC_803细胞生长的影响[J].天然产物研究与开发,2009,21(6):952-955. |
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| 作者姓名： | 韩澄 聂少平 黄丹菲 陈一睛 谢建华 谢明勇 |
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| 作者单位： | 南昌大学食品科学与技术国家重点实验室,南昌,330047 |
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| 基金项目： | 教育部长江学者和创新团队发展计划，食品科学与技术国家重点实验室目标导向项目 |
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| 摘 要： | 本文研究青钱柳多糖(polysaccharides isolated from Cyclocarya paliurus(Batal.)Iljinskjk,PCP)对人胃癌MGC_803细胞生长的影响.采用噻唑蓝(MTT)法检测PCP对MGC_803细胞生长的影响;Annexin法检测PCP对MGC_803细胞诱导凋亡的作用.实验结果表明PCP在50、100、200、400 μg/mL浓度条件下,均可极显著性抑制人胃癌MGC_803细胞生长(P＜0.01),抑制率可达65.07%,细胞凋亡率可达25,44%.说明青钱柳多糖具有抑制人胃癌MGC_803细胞生长的生物活性.
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| 关 键 词： | 青钱柳多糖 人胃癌MGC_803细胞 细胞凋亡 |
Effects of Polysaccharides from Cyclocarya paliurus(Batal.)Iljinskjk on Growth of MGC_803 Cells |
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| HAN Cheng,NIE Shao-ping,HUANG Dan-fei,CHEN Yi-qing,XIE Jian-hua,XIE Ming-yong.Effects of Polysaccharides from Cyclocarya paliurus(Batal.)Iljinskjk on Growth of MGC_803 Cells[J].Natural Product Research and Development,2009,21(6):952-955. |
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| Authors: | HAN Cheng NIE Shao-ping HUANG Dan-fei CHEN Yi-qing XIE Jian-hua XIE Ming-yong |
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| Abstract: | The study was designed to investigate the regular effects of polysaccharides isolated from Cyclocarya paliurus(Batal.)Iljinskjk(PCP)on human gastric cancer cell line MGC_803 in vitro.MTT assay was applied to detect the proliferation activity of MGC_803 cells which were treated by PCP;the apoptosis inducing effects of PCP to MGC_803 cells were treated by Annexin assay.In this study,PCP can inhibit the proliferation of MGC_803 extremely(P＜0.01)at the concentration of 50,100,200,400 μg/mL.The biggest inhibition rate was up to 65.07% and the apoptosis rate was 25.44%.Polysaccharide from Cyclocarya paliurus(Batal.)Iljinskjk has antitumor bioactivities on human gastric cancer cell line MGC803. |
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| Keywords: | MTY Cyclocarya paliurus(Batal )Iljinskjk polysaccharides MGC_803 cells MTT cell apoptosis |
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