Neopetrosiquinones A and B, sesquiterpene benzoquinones isolated from the deep-water sponge Neopetrosia cf. proxima |
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| Authors: | Winder Priscilla L Baker Heather L Linley Patricia Guzmán Esther A Pomponi Shirley A Diaz M Cristina Reed John K Wright Amy E |
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| Institution: | Harbor Branch Oceanographic Institute at Florida Atlantic University, Marine Biomedical and Biotechnology Research Program, Fort Pierce, FL 34946, United States. |
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| Abstract: | Two new marine-derived sesquiterpene benzoquinones which we designate as neopetrosiquinones A (1) and B (2), have been isolated from a deep-water sponge of the family Petrosiidae. The structures were elucidated on the basis of their spectroscopic data. Compounds 1 and 2 inhibit the in vitro proliferation of the DLD-1 human colorectal adenocarcinoma cell line with IC(50) values of 3.7 and 9.8 μM, respectively, and the PANC-1 human pancreatic carcinoma cell line with IC(50) values of 6.1 and 13.8 μM, respectively. Neopetrosiquinone A (1) also inhibited the in vitro proliferation of the AsPC-1 human pancreatic carcinoma cell line with an IC(50) value of 6.1 μM. The compounds are structurally related to alisiaquinone A, cyclozonarone, and xestoquinone. |
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