| 蛋白酶活化受体1在不同肿瘤中的研究进展 |
| |
| 引用本文： | 张立华,蒋星军,冯湘玲,刘卫东,张树菊,任彩萍.蛋白酶活化受体1在不同肿瘤中的研究进展[J].生命科学研究,2012,16(3):277-282. |
| |
| 作者姓名： | 张立华 蒋星军 冯湘玲 刘卫东 张树菊 任彩萍 |
| |
| 作者单位： | 1. 中南大学肿瘤研究所,中国湖南长沙,410078
2. 中南大学湘雅医院,中国湖南长沙,410078 |
| |
| 基金项目： | 国家973项目，教育部新世纪优秀人才支持计划资助项目，中南大学杰出青年培育资助项目，国家自然科学基金，湖南省自然科学基金，中南大学贵重仪器设备开放共享基金 |
| |
| 摘 要： | 人蛋白酶活化受体1(PAR-1)是蛋白酶活化受体家族的成员之一.它活化方式特殊,生物学功能广泛.已经证实PAR-1在黑色素瘤、乳腺癌、胃癌、鼻咽癌、前列腺癌癌旁间质、肝癌、结肠癌等组织中表达上调,在肿瘤细胞的增殖和转移过程中发挥重要作用,可作为患者临床病理分期及预后的标志物.
|
| 关 键 词： | 蛋白酶活化受体1(PAR-1) 上调 转移 预后 |
Progresses on Protease-activated Receptor 1 in Various Tumors |
| |
| ZHANG Li-hua
,
JIANG Xing-jun
,
FENG Xiang-ling
,
LIU Wei-dong
,
ZHANG Shu-ju
,
REN Cai-ping.Progresses on Protease-activated Receptor 1 in Various Tumors[J].Life Science Research,2012,16(3):277-282. |
| |
| Authors: | ZHANG Li-hua JIANG Xing-jun FENG Xiang-ling LIU Wei-dong ZHANG Shu-ju REN Cai-ping |
| |
| Institution: | a(a.Cancer Research Institute;b Xiangya Hospital,Central South University,Changsha 410078,Hunan,China) |
| |
| Abstract: | Protease-activated receptor-1(PAR-1) is a member of protease-activated receptor family.With special activation manner and various functions,PAR-1 has been verified to be up-regulated in melanoma,breast cancer,gastric cancer,nasopharyngeal carcinoma,adjacent stroma of prostate cancer,lung cancer,and colorectal cancer.It plays important roles in tumor proliferation and metastasis,and is regarded as a promising biomarker for clinical pathological staging and prognosis in various malignancies. |
| |
| Keywords: | protease-activated receptor-1(PAR-1) up-regulation metastasis prognosis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
