Farmer's peptidomimetic approach: A target for synthetic combinatorial libraries |
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| Authors: | Jung Lee Ronald E Barrett and Philippe R Bovy |
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| Institution: | (1) Affymax Research Institute, 4001 Miranda Avenue, 94304 Palo Alto, CA, U.S.A.;(2) Synthelabo, 10 rue des Carrières, F-92500 Rueil, France |
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| Abstract: | Summary Two combinatorial libraries of 1296 compounds each were synthesized from two sets of carboxylic acid building blocks and two diamino acid scaffolds. The library was designed to produce low-molecular-weight compounds in a soluble form, to be assayed as potential ligands for peptidergic receptors. |
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| Keywords: | Peptidomimetic Nonpeptide combinatorial libraries Solid-phase synthesis Photolabile linker |
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