Effect of Mg++ on the Activity of Vancomycin Against Escherichia coli |
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| Authors: | A. D. Russell I. L. Thomas |
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| Affiliation: | Departments of Pharmaceutics and Pharmaceutical Chemistry, Welsh School of Pharmacy, Welsh College of Advanced Technology, Cardiff, Wales |
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| Abstract: | Mg++ ions alleviate the inhibitory effect of vancomycin on Escherichia coli. This is not due to the formation of an antibacterial-inactive complex. It is suggested that vancomycin and Mg++ compete for a receptor site, or sites, on (or in) the bacterial cell. |
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