The increase of alpha-melanocyte-stimulating hormone in the plasma of chronic fatigue syndrome patients |
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| Authors: | Nobue Shishioh-Ikejima Tokiko Ogawa Kouzi Yamaguti Yasuyoshi Watanabe Hirohiko Kuratsune Hiroshi Kiyama |
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| Affiliation: | (1) Department of Anatomy & Neurobiology, Osaka City University, Graduate School of Medicine, Osaka 545-8585, Japan;(2) Department of Physiology, Osaka City University, Graduate School of Medicine, Osaka 545-8585, Japan;(3) Center for Molecular Imaging Science, RIKEN, Kobe Hyogo, 650-0047, Japan;(4) Faculty of Health Science for Welfare, Kansai University of Welfare Sciences, Kashihara, Osaka 582-0026, Japan;(5) Department of Comparative Pathophysiology, Graduate School of Agricultural & Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan |
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| Abstract: | Background Despite extensive research, no reliable biological marker for chronic fatigue syndrome (CFS) has yet been identified. However, hyperactivation of melanotrophs in the pituitary gland and increased levels of plasma alpha-melanocyte-stimulating hormone (α-MSH) have recently been detected in an animal model of chronic stress. Because CFS is considered to be caused partly by chronic stress events, increased α-MSH plasma levels may also occur in CFS patients. We therefore examined α-MSH levels in CFS patients. |
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