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In vitro toxicity and antidiabetic activity of a newly developed polyherbal formulation (MAC-ST/001) in streptozotocin-induced diabetic Wistar rats |
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| Authors: | Deepak Yadav Anis Ahmad Chaudhary Veena Garg Mohammad Faiyaz Anwar Md Mahfooz-ur Rahman Sayed Sakir Jamil Haider Ali Khan Mohd Asif |
| Affiliation: | 1. Drug Standardization Lab, Department of Ilmul-Advia, F/O Medicine, Jamia Hamdard, New Delhi, 110062, India 2. Department of Bioscience and Biotechnolgy, Banasthali University, Rajasthan, India 3. Department of Chemistry, F/O Science, Jamia Hamdard, New Delhi, India 4. Department of Molijat, F/O Medicine, Jamia Hamdard, New Delhi, India 5. Department of Elementology and Toxicology, F/O Science, Jamia Hamdard, New Delhi, India |
| Abstract: | The present study was designed to investigate the hypoglycemic effect of an aqueous extract of MAC-ST/001 (a new polyherbal formulation) which was given once daily to rats at different doses. The animals were divided into diabetic and nondiabetic control groups. The duration of each experiment lasted from 1 week to 1 month, and the results were compared with that of the standard hypoglycemic drug glibenclamide (10 mg/kg), which was given once daily. In this study, biochemical and histopathological parameters were studied in streptozotacin (STZ) (single intraperitoneal injection of 55 mg/kg)-induced diabetic rats. The diabetic rats showed a significant (p?p? |
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