Escherichia coli O157:H7 induces attaching-effacing lesions in large intestinal mucosal explants from adult cattle |
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Authors: | Baehler A A Moxley R A |
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Institution: | Department of Veterinary Sciences, Institute of Agriculture and Natural Resources, University of Nebraska-Lincoln, Lincoln, NE, USA. |
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Abstract: | Attaching-effacing (A/E) lesions following natural and experimental infection with Escherichia coli O157:H7 have been seen in neonatal and 3-4-month-old weanling but not older cattle. To test the hypothesis that the adult bovine large intestinal epithelium is resistant to the development of A/E lesions, colonic and rectal mucosal tissue explants from 18-month-old steers were inoculated with E. coli O157:H7 and examined. Epithelial cells of inoculated explants developed A/E lesions at the bacterial attachment sites, providing evidence that the large intestinal mucosal epithelium may be a site of infection that contributes to carriage of E. coli O157:H7 in adult cattle. |
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Keywords: | Attaching-effacing Cattle Large intestine Explant Escherichia coli O157:H7 |
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